Tech Tips

Comparison of Regular Tablets With Mini-Tablets Prepared As An Alternative To Pellets.

Stuart C. Porter, Gary Bubb, Dev K. Mehra, and Robert Sedlock

Purpose: To use a D.o.E. approach to examine the influence of three formulation variables on drug release from matrix modified-release tablets coated with various levels of a modified-release film coating, and to explore the merits of using mini-tablets, as an alternative to pellets, as a multiparticulate delivery system.

Purpose: Evaluate the difference in tablet press compression dwell time as a function of D and B tooling and different head styles such as domed and standard TSM. Additionally, compare the dwell time computed as a function of the tangential velocity and the head flat to that calculated from computer programs using a 90% of peak force.

 Purpose: Develop a procedure to optimize the required lubricant level for tabletting operations.